Matov A, Applegate K, Kumar P, Thoma C, Krek W, Danuser G, Wittmann T (2010) Analysis of microtubule dynamic instability using a plus-end growth marker. Sept D, Baker NA, McCammon JA (2003) The physical basis of microtubule structure and stability. Īyoub AT, Staelens M, Prunotto A, Deriu MA, Danani A, Klobukowski M, Tuszynski JA (2017) Explaining the microtubule energy balance: contributions due to dipole moments, charges, van der waals and solvation energy. J Biol Chem 267:7995–8006ĭesai A, Mitchison TJ (1997) Microtubule polymerization dynamics. Gildersleeve RF, Cross AR, Cullen KE, Fagen AP, Williams RC Jr (1992) Microtubules grow and shorten at intrinsically variable rates. įischer RS, Fowler VM (2015) Thematic minireview series: the state of the cytoskeleton in 2015. Goodson HV, Jonasson EM (2018) Microtubules and microtubule-associated proteins. Ilan Y (2019) Microtubules: from understanding their dynamics to using them as potential therapeutic targets. Hamant O, Inoue D, Bouchez D, Dumais J, Mjolsness E (2019) Are microtubules tension sensors? Nat Commun 10:2360. Ilan-Ber T, Ilan Y (2019) The role of microtubules in the immune system and as potential targets for gut-based immunotherapy. Moujaber O, Stochaj U (2020) The cytoskeleton as regulator of cell signaling pathways. Needleman DJ, Ojeda-Lopez MA, Raviv U, Ewert K, Miller HP, Wilson L, Safinya CR (2005) Radial compression of microtubules and the mechanism of action of taxol and associated proteins. Hameroff S, Penrose R (2014) Consciousness in the universe: a review of the “Orch OR” theory. īrookes JC (2017) Quantum effects in biology: golden rule in enzymes, olfaction, photosynthesis and magnetodetection. Marais A, Adams B, Ringsmuth AK, Ferretti M, Gruber JM, Hendrikx R, Schuld M, Smith SL, Sinayskiy I, Kruger TPJ, Petruccione F, van Grondelle R (2018) The future of quantum biology. Ilan Y (2019) Randomness in microtubule dynamics: an error that requires correction or an inherent plasticity required for normal cellular function? Cell Biol Int 43:739–748. īurbank KS, Mitchison TJ (2006) Microtubule dynamic instability. Mitchison T, Kirschner M (1984) Dynamic instability of microtubule growth. Khoury T, Ilan Y (2019) introducing patterns of variability for overcoming compensatory adaptation of the immune system to immunomodulatory agents: a novel method for improving clinical response to anti-TNF therapies. Kenig A, Ilan Y (2019) A personalized signature and chronotherapy-based platform for improving the efficacy of sepsis treatment. Ilan Y (2019) Generating randomness: making the most out of disordering a false order into a real one. Ilan Y (2019) beta-glycosphingolipids as mediators of both inflammation and immune tolerance: a manifestation of randomness in biological systems. Ilan Y (2020) Advanced tailored randomness: a novel approach for improving the efficacy of biological systems. Ilan Y (2019) Overcoming randomness does not rule out the importance of inherent randomness for functionality. Ongoing trials test the effects of this platform on various disorders. The platform can regulate the use of MT-targeting drugs to improve the response to chronic therapies. The described system quantifies MT-dependent variability patterns combined with additional personalized signatures to improve organ function in a subject-tailored manner. The paper presents the option for targeting MTs to trigger dynamic improvement in cell plasticity, regulate energy transfer, and possibly control quantum effects in biological systems. The paper reviews the current data on MTs and their potential roles as energy-transfer cellular structures and presents how variability can improve the function of biological systems in an individualized manner. It results from a balance between attractive and repulsive forces between tubulin dimers. The dynamic instability of MTs manifests itself by the coexistence of growth and shortening, or polymerization and depolymerization. MTs are a platform for energy transfer in cells. Microtubules (MTs) play a role in structural integrity, cell motility, material transport, and force generation during mitosis, and dynamic instability exemplifies the variability in the proper function of MTs. Variability characterizes the complexity of biological systems and is essential for their function.
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